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In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity

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This typically includes physical examination, review of all current medications, assessment of kidney and liver function through blood tests, and possibly cardiac evaluation with electrocardiogram or echocardiography